Arash Nabbi
Senior Scientist, Oncology R&D, AstraZeneca Canada
AstraZeneca Canada
1004 Middlegate Rd
Mississauga, ON
L4Y 1M4
I am a computational biologist and a pharmacist focusing on biomarker research for immuno-oncology. My training spans across computational and experimental approaches in several adult and childhood cancers. My work involves applying advanced technologies to determine mechanisms of immunotherapy and identify predictive biomarkers for immunotherapy.
I pursued my post-doctoral training in Dr. Trevor Pugh’s laboratory at the Princess Margaret Cancer Center located in Toronto, ON. I had the opportunity to work on several translational research projects focused on the immunogenomics of pediatric cancers.
I hold a PhD in cancer biology from the Cumming school of medicine at the University of Calgary. During my studies, I focused on investigating epigenetic and post-translational regulation of Androgen Receptor pathway and its impact on the progression of prostate cancer.
Research interests:
- Predictive immune biomarkers to guide prospective clinical trials
- Identification of novel targets of cancer immunotherapy using a combination of computational and experimental approaches
- Tumour-Immune evolution over the course of disease/treatment
news
| Jul 04, 2024 | Thrilled to announce that I will be joining AstraZeneca as a Senior Scientist in the Oncology R&D! I am excited to extend my postdoctoral work, this time focusing on biomarker discovery for immuno-oncology in adult cancers. |
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| Jun 28, 2024 | Thrilled to have participated in the 4th annual Arthur and Sandra Irving Cancer Immunology Symposium with all-star scientists. The Irving Cancer Immunology Symposium Many thanks to the Irving family for sponsoring this amazing mentorship program for junior investigators. |
| Sep 11, 2023 | Thrilled to announce that my postdoctoral work on immunogenomic analysis of pediatric CNS tumors and neurobastomas is now online at Genome Medicine. I would like to thank collaborators at the German Cancer Center (DKFZ), Children’s Hospital of Philadelphia, and members of the PROFYLE program in Canada for their help and input during this project. Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours |
| Apr 28, 2023 | Great to have my work highlighted in the News & Views section of Nature Cancer. Appreciate authors Drs. Neeson & Ekert! Harnessing immune checkpoint trial data in pediatric cancer |
| Apr 20, 2023 | Thrilled to see my work on biomarker analysis of pediatric tumors treated with atezolizumab online in Nature Cancer. I would like to thank collaborators at Genentech/Roche as well as funders for this important study highlighting the value of personalized immunotherapy in pediatric cancers. Multimodal immunogenomic biomarker analysis of tumors from pediatric patients enrolled to a phase 1-2 study of single-agent atezolizumab |